Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeare...

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Veröffentlicht in:Aging Cell
Hauptverfasser: MacRae, Sheila L, Zhang, Quanwei, Lemetre, Christophe, Seim, Inge, Calder, Robert B, Hoeijmakers, Jan, Suh, Yousin, Gladyshev, Vadim N, Seluanov, Andrei, Gorbunova, Vera, Vijg, Jan, Zhang, Zhengdong D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364841/
https://ncbi.nlm.nih.gov/pubmed/25645816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12314
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