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Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeare...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: MacRae, Sheila L, Zhang, Quanwei, Lemetre, Christophe, Seim, Inge, Calder, Robert B, Hoeijmakers, Jan, Suh, Yousin, Gladyshev, Vadim N, Seluanov, Andrei, Gorbunova, Vera, Vijg, Jan, Zhang, Zhengdong D
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364841/
https://ncbi.nlm.nih.gov/pubmed/25645816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12314
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