α-synuclein impairs autophagosome maturation through abnormal actin stabilization

Vesicular trafficking defects, particularly those in the autophagolysosomal system, have been strongly implicated in the pathogenesis of Parkinson’s disease and related α-synucleinopathies. However, mechanisms mediating dysfunction of membrane trafficking remain incompletely understood. Using a Dros...

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Udgivet i:PLoS Genet
Main Authors: Sarkar, Souvarish, Olsen, Abby L., Sygnecka, Katja, Lohr, Kelly M., Feany, Mel B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895402/
https://ncbi.nlm.nih.gov/pubmed/33556113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009359
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