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Pentostatin Antagonizes the Antiviral Activity of MBX-2168 by Inhibiting the Biosynthesis of the Active Compound
MBX-2168 has a mechanism of action similar to that of acyclovir (ACV) and ganciclovir (GCV), but two unique steps differentiate this drug from ACV/GCV. First, MBX-2168 is, at least partially, phosphorylated by the endogenous cellular kinase TAOK3 to a monophosphate. The second involves the removal o...
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| Publicado no: | Antiviral Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7893631/ https://ncbi.nlm.nih.gov/pubmed/33476709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2021.105018 |
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