Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein

X-linked inhibitor of apoptosis protein (XIAP) is a member of inhibitor of apoptosis protein (IAP) family responsible for neutralizing the caspases-3, caspases-7, and caspases-9. Overexpression of the protein decreased the apoptosis process in the cell and resulting development of cancer. Different...

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Vydáno v:Sci Rep
Hlavní autoři: Opo, Firoz A. Dain Md, Rahman, Mohammed M., Ahammad, Foysal, Ahmed, Istiak, Bhuiyan, Mohiuddin Ahmed, Asiri, Abdullah M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892887/
https://ncbi.nlm.nih.gov/pubmed/33603068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83626-x
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