Deletion of Socs3 in LysM(+) cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy

BACKGROUND: We generated a mouse model of primary microglial dysfunction by deleting two negative immune regulatory genes, Cx3cr1 and Socs3 (in LysM(+) cells). This study aimed to understand how primary microglial dysfunction impacts retinal neurons during aging. METHODS: The LysMCre-Socs3(fl/fl)Cx3...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Du, Xuan, Penalva, Rosana, Little, Karis, Kissenpfennig, Adrien, Chen, Mei, Xu, Heping
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891019/
https://ncbi.nlm.nih.gov/pubmed/33602265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00432-9
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