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Deletion of Socs3 in LysM(+) cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy
BACKGROUND: We generated a mouse model of primary microglial dysfunction by deleting two negative immune regulatory genes, Cx3cr1 and Socs3 (in LysM(+) cells). This study aimed to understand how primary microglial dysfunction impacts retinal neurons during aging. METHODS: The LysMCre-Socs3(fl/fl)Cx3...
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| Udgivet i: | Mol Neurodegener |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7891019/ https://ncbi.nlm.nih.gov/pubmed/33602265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00432-9 |
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