Immunostimulatory siRNA with a uridine bulge leads to potent inhibition of HBV and activation of innate immunity

BACKGROUND: Hepatitis B virus (HBV) infection is difficult to cure. HBV-specific immune tolerance plays a key role in HBV persistence, and enhancing cellular and humoral immunity will improve the control of HBV infection. The purpose of the study was to explore the anti-HBV and immunostimulatory eff...

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Udgivet i:Virol J
Main Authors: Lan, Tingyu, Wei, Zhiqiang, He, Yulin, Wan, Song, Liu, Li, Cheng, Bin, Li, Ruimin, Chen, Hongxia, Liu, Guohua, Meng, Zhongji
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890953/
https://ncbi.nlm.nih.gov/pubmed/33602251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-021-01509-z
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