Variability in the UDP-glucuronosyltransferase 1A1 (UGT1A1) promotor in a HIV-infected Portuguese population

Introduction: Dolutegravir is an HIV-1 integrase inhibitor (INI) recently approved for the treatment of HIV infection and is metabolized by UGT1A1 [1]. This protein is responsible for the glucuronidation of many compounds, and some functional polymorphisms in the UGT1A1 gene results in a decrease of...

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Bibliografiske detaljer
Udgivet i:Ann Med
Main Authors: Ferraz, Adriana, Moscovciuc, Alina, Fernandes, Ana, Cruz, João Paulo, Bandarra, Susana, Mascarenhas, Paulo, Martins, Rui, Barahona, Isabel, Ribeiro, Ana Clara
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Pharmacy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888746/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07853890.2018.1561724
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