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Novel Application of Hot Melt Extrusion Technology for Preparation and Evaluation of Valacyclovir Hydrochloride Ocular Inserts

The objective of this study was to investigate the processability of hot-melt extrusion (HME) to formulate ocular inserts of valacyclovir hydrochloride and evaluate the in vivo bioavailability of the formulation. To optimize the formulation of this drug, different physical mixtures of the polymers a...

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Detalhes bibliográficos
Publicado no:AAPS PharmSciTech
Main Authors: Shadambikar, Gauri, Marathe, Sushrut, Patil, Akash, Joshi, Rohit, Bandari, Suresh, Majumdar, Soumyajit, Repka, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7886274/
https://ncbi.nlm.nih.gov/pubmed/33447869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-020-01916-5
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