CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes

Nuclear histone deacetylase 4 (HDAC4) represses MEF2-mediated transcription, implicated in the development of heart failure. CaMKII-dependent phosphorylation drives nucleus-to-cytoplasm HDAC4 shuttling, but protein kinase A (PKA) is also linked to HDAC4 translocation. However, the interplay of CaMKI...

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Publicado en:Basic Res Cardiol
Main Authors: Helmstadter, Kathryn G., Ljubojevic-Holzer, Senka, Wood, Brent M., Taheri, Khanha D., Sedej, Simon, Erickson, Jeffrey R., Bossuyt, Julie, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2021
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Original Contribution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884572/
https://ncbi.nlm.nih.gov/pubmed/33590335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-021-00850-2
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