Structural Insights into the Recognition of Mono- and Diacetylated Histones by the ATAD2B Bromodomain

Bromodomains exhibit preferences for specific patterns of post-translational modifications on core and variant histone proteins. We examined the ligand specificity of the ATAD2B bromodomain and compared it to its closely related paralogue in ATAD2. We show that the ATAD2B bromodomain recognizes mono...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Lloyd, Jonathan T., McLaughlin, Kyle, Lubula, Mulu Y., Gay, Jamie C., Dest, Andrea, Gao, Cong, Phillips, Margaret, Tonelli, Marco, Cornilescu, Gabriel, Marunde, Matthew R., Evans, Chiara M., Boyson, Samuel P., Carlson, Samuel, Keogh, Michael-Christopher, Markley, John L., Frietze, Seth, Glass, Karen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884259/
https://ncbi.nlm.nih.gov/pubmed/33084328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01178
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