Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 protein nonetheless contributes to several cancer-r...

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Vydáno v:eLife
Hlavní autoři: Palavalli Parsons, Lavanya H, Challa, Sridevi, Gibson, Bryan A, Nandu, Tulip, Stokes, MiKayla S, Huang, Dan, Lea, Jayanthi S, Kraus, W Lee
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884071/
https://ncbi.nlm.nih.gov/pubmed/33475085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60481
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