Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 protein nonetheless contributes to several cancer-r...

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發表在:eLife
Main Authors: Palavalli Parsons, Lavanya H, Challa, Sridevi, Gibson, Bryan A, Nandu, Tulip, Stokes, MiKayla S, Huang, Dan, Lea, Jayanthi S, Kraus, W Lee
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2021
主題:
Biochemistry and Chemical Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884071/
https://ncbi.nlm.nih.gov/pubmed/33475085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60481
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