Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

[Image: see text] In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13–15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Jin, Fangfang, Hu, Qiyue, Fei, Hongbo, Lv, Hejun, Wang, Shenglan, Gui, Bin, Zhang, Junzhen, Tu, Wangyang, Zhang, Yun, Zhang, Lei, Wan, Hong, Zhang, Limin, Hu, Bin, Yang, Fanglong, Bai, Chang, He, Feng, Zhang, Lianshan, Tao, Weikang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2021
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883375/
https://ncbi.nlm.nih.gov/pubmed/33603965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00443
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