Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7

Epigenetic gene silencing by aberrant DNA methylation leads to loss of key cellular pathways in tumorigenesis. In order to analyze the effects of DNA methylation on prostate cancer, we established LNCaP-derived human prostate cancer cells that can pharmacologically induce global reactivation of hype...

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Detalhes bibliográficos
Publicado no:Dis Markers
Main Authors: Miyauchi, Toshiya, Takahashi, Masahiro, Mitsuzuka, Koji, Saiki, Yuriko, Okubo, Teppei, Vertino, Paula M., Goto, Akiteru, Arai, Yoichi, Horii, Akira, Fukushige, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881737/
https://ncbi.nlm.nih.gov/pubmed/33628338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/8858905
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