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Targeted TET oxidase activity through methyl‐CpG‐binding domain extensively suppresses cancer cell proliferation

DNA methyltransferase (DNMT) inhibitors are epigenetic drugs used to treat myelodysplastic syndrome. They not only induce DNA demethylation but also have significant cytostatic and cytotoxic effects; however, the relationships between these characteristics have not been established yet due to the la...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Mizuguchi, Yasuhiko, Saiki, Yuriko, Horii, Akira, Fukushige, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055179/
https://ncbi.nlm.nih.gov/pubmed/27457352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.830
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