Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)

Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ALS. FUS also undergoes liquid–liquid phase separation (LLPS) to accumulate in stress granu...

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Publicado en:Sci Rep
Main Authors: Gonzalez, Abner, Mannen, Taro, Çağatay, Tolga, Fujiwara, Ayano, Matsumura, Hiroyoshi, Niesman, Ashley B., Brautigam, Chad A., Chook, Yuh Min, Yoshizawa, Takuya
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881136/
https://ncbi.nlm.nih.gov/pubmed/33580145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83196-y
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