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Conformational Heterogeneity of Karyopherinβ2 Is Segmental

Karyopherinβ2 (Kapβ2) or transportin imports numerous RNA binding proteins into the nucleus. Kapβ2 binds substrates in the cytoplasm and targets them through the nuclear pore complex, where RanGTP dissociates them in the nucleus. Here we report the 3.0Å crystal structure of unliganded Kapβ2, which c...

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Autores principales: Cansizoglu, Ahmet E., Chook, Yuh Min
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437625/
https://ncbi.nlm.nih.gov/pubmed/17997969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.09.009
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