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Conformational Heterogeneity of Karyopherinβ2 Is Segmental
Karyopherinβ2 (Kapβ2) or transportin imports numerous RNA binding proteins into the nucleus. Kapβ2 binds substrates in the cytoplasm and targets them through the nuclear pore complex, where RanGTP dissociates them in the nucleus. Here we report the 3.0Å crystal structure of unliganded Kapβ2, which c...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437625/ https://ncbi.nlm.nih.gov/pubmed/17997969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.09.009 |
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