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Karyopherin-β2 recognition of a PY-NLS variant that lacks the proline-tyrosine motif
Karyopherin-β2 or Transportin-1 binds proline-tyrosine nuclear localization signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall positive charge, and binding epitopes composed of an N-terminal hydrophobic or basic motif and a C-terminal R-X(2-5)P-Y motif. The N-term...
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| 出版年: | Structure |
|---|---|
| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5053885/ https://ncbi.nlm.nih.gov/pubmed/27618664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.07.018 |
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