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Pharmacological inhibition of the mitochondrial Ca(2+) uniporter: relevance for pathophysiology and human therapy

Mitochondrial Ca(2+) uptake has long been considered crucial for meeting the fluctuating energy demands of cells in the heart and other tissues. Increases in mitochondrial matrix [Ca(2+)] drive mitochondrial ATP production via stimulation of Ca(2+)-sensitive dehydrogenases. Mitochondria-targeted sen...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Márta, Katalin, Hasan, Prottoy, Rodríguez-Prados, Macarena, Paillard, Melanie, Hajnóczky, György
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880870/
https://ncbi.nlm.nih.gov/pubmed/33035551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.09.014
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