Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models

How particular bone marrow niche factors contribute to the leukemogenic activities of leukemia-initiating cells (LICs) remains largely unknown. Here, we showed that ATP levels were markedly increased in the bone marrow niches of mice with acute myeloid leukemia (AML), and LICs preferentially localiz...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: He, Xiaoxiao, Wan, Jiangbo, Yang, Xiaona, Zhang, Xiuze, Huang, Dan, Li, Xie, Zou, Yejun, Chen, Chiqi, Yu, Zhuo, Xie, Li, Zhang, Yaping, Liu, Ligen, Li, Shangang, Zhao, Yuzheng, Shao, Hongfang, Yu, Ye, Zheng, Junke
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2021
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880412/
https://ncbi.nlm.nih.gov/pubmed/33301426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140242
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