Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models

How particular bone marrow niche factors contribute to the leukemogenic activities of leukemia-initiating cells (LICs) remains largely unknown. Here, we showed that ATP levels were markedly increased in the bone marrow niches of mice with acute myeloid leukemia (AML), and LICs preferentially localiz...

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Опубликовано в: :J Clin Invest
Главные авторы: He, Xiaoxiao, Wan, Jiangbo, Yang, Xiaona, Zhang, Xiuze, Huang, Dan, Li, Xie, Zou, Yejun, Chen, Chiqi, Yu, Zhuo, Xie, Li, Zhang, Yaping, Liu, Ligen, Li, Shangang, Zhao, Yuzheng, Shao, Hongfang, Yu, Ye, Zheng, Junke
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880412/
https://ncbi.nlm.nih.gov/pubmed/33301426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140242
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