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Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus

Mureidomycins (MRDs), a group of unique uridyl-peptide antibiotics, exhibit antibacterial activity against the highly refractory pathogen Pseudomonas aeruginosa. Our previous study showed that the cryptic MRD biosynthetic gene cluster (BGC) mrd in Streptomyces roseosporus NRRL 15998 could not be act...

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Detalhes bibliográficos
Publicado no:Sci China Life Sci
Main Authors: Liu, Ning, Guan, Hanye, Niu, Guoqing, Jiang, Lingjuan, Li, Yue, Zhang, Jihui, Li, Jine, Tan, Huarong
Formato: Artigo
Idioma:Inglês
Publicado em: Science China Press 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880210/
https://ncbi.nlm.nih.gov/pubmed/33580428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11427-020-1892-3
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