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Molecular mechanism of mureidomycin biosynthesis activated by introduction of an exogenous regulatory gene ssaA into Streptomyces roseosporus

Mureidomycins (MRDs), a group of unique uridyl-peptide antibiotics, exhibit antibacterial activity against the highly refractory pathogen Pseudomonas aeruginosa. Our previous study showed that the cryptic MRD biosynthetic gene cluster (BGC) mrd in Streptomyces roseosporus NRRL 15998 could not be act...

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Bibliografiske detaljer
Udgivet i:Sci China Life Sci
Main Authors: Liu, Ning, Guan, Hanye, Niu, Guoqing, Jiang, Lingjuan, Li, Yue, Zhang, Jihui, Li, Jine, Tan, Huarong
Format: Artigo
Sprog:Inglês
Udgivet: Science China Press 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7880210/
https://ncbi.nlm.nih.gov/pubmed/33580428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11427-020-1892-3
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