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ARL8 Relieves SKIP Autoinhibition to Enable Coupling of Lysosomes to Kinesin-1

Long-range movement of organelles within the cytoplasm relies on coupling to microtubule motors, a process that is often mediated by adaptor proteins. In many cases, this coupling involves organelle- or adaptor-induced activation of the microtubule motors by conformational reversal of an autoinhibit...

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Publicat a:Curr Biol
Autors principals: Keren-Kaplan, Tal, Bonifacino, Juan S.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878431/
https://ncbi.nlm.nih.gov/pubmed/33232665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2020.10.071
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