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A Ragulator–BORC interaction controls lysosome positioning in response to amino acid availability

Lysosomes play key roles in the cellular response to amino acid availability. Depletion of amino acids from the medium turns off a signaling pathway involving the Ragulator complex and the Rag guanosine triphosphatases (GTPases), causing release of the inactive mammalian target of rapamycin complex...

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Foilsithe in:J Cell Biol
Main Authors: Pu, Jing, Keren-Kaplan, Tal, Bonifacino, Juan S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716277/
https://ncbi.nlm.nih.gov/pubmed/28993468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703094
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