Targeting PAK4 inhibits Ras-mediated signaling and multiple oncogenic pathways in high-risk Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most prevalent pediatric soft tissue sarcoma. Multimodal treatment including surgery and traditional chemotherapy with radiotherapy have contributed to improvements in overall survival rates. However, patients with recurrent or metastatic disease have 5-year survival ra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Dasgupta, Atreyi, Sierra, Laura, Tsang, Susan V., Kurenbekova, Lyazat, Patel, Tajhal, Rajapakse, Kimal, Shuck, Ryan L., Rainusso, Nino, Landesman, Yosef, Unger, Thaddeus, Coarfa, Cristian, Yustein, Jason T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878415/
https://ncbi.nlm.nih.gov/pubmed/33168646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0854
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