Targeting PAK4 inhibits Ras-mediated signaling and multiple oncogenic pathways in high-risk Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most prevalent pediatric soft tissue sarcoma. Multimodal treatment including surgery and traditional chemotherapy with radiotherapy have contributed to improvements in overall survival rates. However, patients with recurrent or metastatic disease have 5-year survival ra...

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Bibliografske podrobnosti
izdano v:Cancer Res
Main Authors: Dasgupta, Atreyi, Sierra, Laura, Tsang, Susan V., Kurenbekova, Lyazat, Patel, Tajhal, Rajapakse, Kimal, Shuck, Ryan L., Rainusso, Nino, Landesman, Yosef, Unger, Thaddeus, Coarfa, Cristian, Yustein, Jason T.
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878415/
https://ncbi.nlm.nih.gov/pubmed/33168646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0854
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