تحميل...
Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
BACKGROUND: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast/ovarian cancer and have been shown to regulate the...
محفوظ في:
| الحاوية / القاعدة: | Redox Biol |
|---|---|
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , |
| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Elsevier
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7878192/ https://ncbi.nlm.nih.gov/pubmed/33581682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101885 |
| الوسوم: |
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