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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
Hypoxia-inducible factor (HIF), a transcriptional complex conserved from Caenorhabditis elegans to vertebrates, plays a pivotal role in cellular adaptation to low oxygen availability. In normoxia, the HIF-α subunits are targeted for destruction by prolyl hydroxylation, a specific modification that p...
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| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Oxford University Press
2003
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC175782/ https://ncbi.nlm.nih.gov/pubmed/12912907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg392 |
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