Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

Hypoxia is a feature of the microenvironment of a growing tumor. The transcription factor NFκB is activated in hypoxia, an event that has significant implications for tumor progression. Here, we demonstrate that hypoxia activates NFκB through a pathway involving activation of IκB kinase-β (IKKβ) lea...

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Main Authors: Cummins, Eoin P., Berra, Edurne, Comerford, Katrina M., Ginouves, Amandine, Fitzgerald, Kathleen T., Seeballuck, Fergal, Godson, Catherine, Nielsen, Jens E., Moynagh, Paul, Pouyssegur, Jacques, Taylor, Cormac T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1643842/
https://ncbi.nlm.nih.gov/pubmed/17114296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602235103
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