Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

BACKGROUND: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast/ovarian cancer and have been shown to regulate the...

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Vydáno v:Redox Biol
Hlavní autoři: Martí, Juan Manuel, Garcia-Diaz, Angel, Delgado-Bellido, Daniel, O'Valle, Francisco, González-Flores, Ariannys, Carlevaris, Onintza, Rodríguez-Vargas, José Manuel, Amé, Jean Christophe, Dantzer, Françoise, King, George L., Dziedzic, Klaudia, Berra, Edurne, de Álava, E., Amaral, A.T., Hammond, Ester M., Oliver, F. Javier
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7878192/
https://ncbi.nlm.nih.gov/pubmed/33581682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101885
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