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Fitness landscape of a dynamic RNA structure

RNA structures are dynamic. As a consequence, mutational effects can be hard to rationalize with reference to a single static native structure. We reasoned that deep mutational scanning experiments, which couple molecular function to fitness, should capture mutational effects across multiple conform...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Soo, Valerie W. C., Swadling, Jacob B., Faure, Andre J., Warnecke, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877785/
https://ncbi.nlm.nih.gov/pubmed/33524037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009353
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