Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATC(nano)), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Batista da Silva, Camila, Volpato, Maria Cristina, Muniz, Bruno Vilela, dos Santos, Cleiton Pita, Serpe, Luciano, Ferreira, Luiz Eduardo Nunes, de Melo, Nathalie Ferreira Silva, Fraceto, Leonardo Fernandes, Groppo, Francisco Carlos, Franz-Montan, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877576/
https://ncbi.nlm.nih.gov/pubmed/33571275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246760
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