Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATC(nano)), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT...

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Udgivet i:PLoS One
Main Authors: Batista da Silva, Camila, Volpato, Maria Cristina, Muniz, Bruno Vilela, dos Santos, Cleiton Pita, Serpe, Luciano, Ferreira, Luiz Eduardo Nunes, de Melo, Nathalie Ferreira Silva, Fraceto, Leonardo Fernandes, Groppo, Francisco Carlos, Franz-Montan, Michelle
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877576/
https://ncbi.nlm.nih.gov/pubmed/33571275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246760
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