Hybrid Hydrogel Composed of Polymeric Nanocapsules Co-Loading Lidocaine and Prilocaine for Topical Intraoral Anesthesia

This study reports the development of nanostructured hydrogels for the sustained release of the eutectic mixture of lidocaine and prilocaine (both at 2.5%) for intraoral topical use. The local anesthetics, free or encapsulated in poly(ε-caprolactone) nanocapsules, were incorporated into CARBOPOL hyd...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Muniz, Bruno Vilela, Baratelli, Diego, Di Carla, Stephany, Serpe, Luciano, da Silva, Camila Batista, Guilherme, Viviane Aparecida, Ribeiro, Lígia Nunes de Morais, Cereda, Cintia Maria Saia, de Paula, Eneida, Volpato, Maria Cristina, Groppo, Francisco Carlos, Fraceto, Leonardo Fernandes, Franz-Montan, Michelle
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299281/
https://ncbi.nlm.nih.gov/pubmed/30568251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36382-4
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