Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia

To determine whether the permeation capacity and analgesic efficacy of articaine (ATC) could be increased and cytotoxicity decreased by encapsulation in poly(ɛ-caprolactone) nanocapsules (ATC(nano)), aiming at local or topical anesthesia in dentistry. Cellular viability was evaluated (using the MTT...

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Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Batista da Silva, Camila, Volpato, Maria Cristina, Muniz, Bruno Vilela, dos Santos, Cleiton Pita, Serpe, Luciano, Ferreira, Luiz Eduardo Nunes, de Melo, Nathalie Ferreira Silva, Fraceto, Leonardo Fernandes, Groppo, Francisco Carlos, Franz-Montan, Michelle
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877576/
https://ncbi.nlm.nih.gov/pubmed/33571275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246760
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