MicroRNA-4516-mediated regulation of MAPK10 relies on 3’UTR cis-acting variants and contributes to the altered risk of Hirschsprung disease

BACKGROUND: Hirschsprung disease (HSCR) is a life-threatening congenital disorder in which the enteric nervous system (ENS) is completely missing from the distal gut. Recent studies have shown that miR-4516 markedly inhibits cell migration, and as one of its potential targets, MAPK10 functions as a...

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Vydáno v:J Med Genet
Hlavní autoři: Wang, Yang, Jiang, Qian, Chakravarti, Aravinda, Cai, Hao, Xu, Ze, Wu, Wenjie, Gu, Beilin, Li, Long, Cai, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877481/
https://ncbi.nlm.nih.gov/pubmed/32066630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2019-106615
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