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A gene regulatory network explains RET–EDNRB epistasis in Hirschsprung disease
Disruptions in gene regulatory networks (GRNs), driven by multiple deleterious variants, potentially underlie complex traits and diseases. Hirschsprung disease (HSCR), a multifactorial disorder of enteric nervous system (ENS) development, is associated with at least 24 genes and seven chromosomal lo...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275776/ https://ncbi.nlm.nih.gov/pubmed/31313802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz149 |
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