Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several uniquely human features: a fixed homozygous missense mutatio...

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Bibliografiske detaljer
Udgivet i:FASEB Bioadv
Main Authors: Siddiqui, Shoib S, Vaill, Michael, Do, Raymond, Khan, Naazneen, Verhagen, Andrea L, Zhang, Wu, Lenz, Heinz‐Josef, Johnson‐Pais, Teresa L, Leach, Robin J, Fraser, Gary, Wang, Charles, Feng, Gen‐Sheng, Varki, Nissi, Varki, Ajit
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876704/
https://ncbi.nlm.nih.gov/pubmed/33615152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2020-00092
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