Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several uniquely human features: a fixed homozygous missense mutatio...

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Detalhes bibliográficos
Publicado no:FASEB Bioadv
Main Authors: Siddiqui, Shoib S, Vaill, Michael, Do, Raymond, Khan, Naazneen, Verhagen, Andrea L, Zhang, Wu, Lenz, Heinz‐Josef, Johnson‐Pais, Teresa L, Leach, Robin J, Fraser, Gary, Wang, Charles, Feng, Gen‐Sheng, Varki, Nissi, Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876704/
https://ncbi.nlm.nih.gov/pubmed/33615152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2020-00092
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