Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens

Synthetic lethal screens are used to discover new combination treatments for cancer. In traditional high-throughput synthetic lethal screens, compounds are tested at a single dose, and hit selection is based on threshold activity values from the variance of the efficacy of the compounds tested. The...

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Bibliographic Details
Published in:J Biomol Screen
Main Authors: Guha, Rajarshi, Griner, Lesley A. Mathews, Keller, Jonathan M., Zhang, Xiaohu, Fitzgerald, David, Antignani, Antonella, Pastan, Ira, Thomas, Craig J., Ferrer, Marc
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876566/
https://ncbi.nlm.nih.gov/pubmed/27112173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057116644890
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