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Simultaneously targeting cancer-associated fibroblasts and angiogenic vessel as a treatment for TNBC
Fibrotic tumor stroma plays an important role in facilitating triple-negative breast cancer (TNBC) progression and chemotherapeutic resistance. We previously reported a rationally designed protein (ProAgio) that targets integrin α(v)β(3) at a novel site. ProAgio induces apoptosis via the integrin. C...
Enregistré dans:
| Publié dans: | J Exp Med |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Rockefeller University Press
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7876552/ https://ncbi.nlm.nih.gov/pubmed/33561195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200712 |
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