Overexpression of Smac by an Armed Vesicular Stomatitis Virus Overcomes Tumor Resistance

Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed by inserting a transgene to express Smac/DIABLO during virus infection (VSV-S). Endogenous Smac in HeLa cel...

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Udgivet i:Mol Ther Oncolytics
Main Authors: Li, Weike, Turaga, Ravi Chakra, Li, Xin, Sharma, Malvika, Enadi, Zahra, Dunham Tompkins, Sydney Nicole, Hardy, Kyle Christian, Mishra, Falguni, Tsao, Jun, Liu, Zhi-ren, Fan, Daping, Luo, Ming
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6610632/
https://ncbi.nlm.nih.gov/pubmed/31312717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2019.05.006
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