An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induce...

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Udgivet i:Sci Rep
Main Authors: Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Dhungana, Hiramani, Huuskonen, Mikko T., Pomeshchik, Yuriy, Savchenko, Ekaterina, Korhonen, Paula K., Singh, Yajuvinder, Wojciechowski, Sara, Lehtonen, Šárka, Kanninen, Katja M., Malm, Tarja, Sirviö, Jouni, Muona, Anu, Koistinaho, Milla, Goldsteins, Gundars, Koistinaho, Jari
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876050/
https://ncbi.nlm.nih.gov/pubmed/33568697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81741-3
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