An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induce...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Keuters, Meike Hedwig, Keksa-Goldsteine, Velta, Dhungana, Hiramani, Huuskonen, Mikko T., Pomeshchik, Yuriy, Savchenko, Ekaterina, Korhonen, Paula K., Singh, Yajuvinder, Wojciechowski, Sara, Lehtonen, Šárka, Kanninen, Katja M., Malm, Tarja, Sirviö, Jouni, Muona, Anu, Koistinaho, Milla, Goldsteins, Gundars, Koistinaho, Jari
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7876050/
https://ncbi.nlm.nih.gov/pubmed/33568697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81741-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados