Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Stroke is a highly debilitating, often fatal disorder for which current therapies are suitable for only a minor fraction of patients. Discovery of novel, effective therapies is hampered by the fact that advanced age, primary age-related tauopathy or comorbidities typical to several types of dementin...

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Pubblicato in:Sci Rep
Autori principali: Huuskonen, Mikko T., Loppi, Sanna, Dhungana, Hiramani, Keksa-Goldsteine, Velta, Lemarchant, Sighild, Korhonen, Paula, Wojciechowski, Sara, Pollari, Eveliina, Valonen, Piia, Koponen, Juho, Takashima, Akihiko, Landreth, Gary, Goldsteins, Gundars, Malm, Tarja, Koistinaho, Jari, Kanninen, Katja M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021977/
https://ncbi.nlm.nih.gov/pubmed/27624652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33176
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