ATP citrate lyase inhibitor triggers endoplasmic reticulum stress to induce hepatocellular carcinoma cell apoptosis via p‐eIF2α/ATF4/CHOP axis

ATP citrate lyase (ACLY), a key enzyme in the metabolic reprogramming of many cancers, is widely expressed in various mammalian tissues. This study aimed to evaluate the effects and mechanisms of ACLY and its inhibitor BMS‐303141 on hepatocellular carcinoma (HCC). In this study, ACLY was highly expr...

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Pubblicato in:J Cell Mol Med
Autori principali: Zheng, Yihu, Zhou, Qingqing, Zhao, Chang, Li, Junjian, Yu, Zhengping, Zhu, Qiandong
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7875901/
https://ncbi.nlm.nih.gov/pubmed/33393219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16235
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