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The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unf...

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Publicado en:Curr Mol Med
Autores principales: Rozpędek, W., Pytel, D., Mucha, B., Leszczyńska, H., Diehl, J. Alan, Majsterek, I.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008685/
https://ncbi.nlm.nih.gov/pubmed/27211800
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