The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress

Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER). The stress in the ER induces the activation of Unf...

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Detaylı Bibliyografya
Yayımlandı:Curr Mol Med
Asıl Yazarlar: Rozpędek, W., Pytel, D., Mucha, B., Leszczyńska, H., Diehl, J. Alan, Majsterek, I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008685/
https://ncbi.nlm.nih.gov/pubmed/27211800
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