Routine Evaluation of Minimal Residual Disease in Myeloma Using Next-Generation Sequencing Clonality Testing: Feasibility, Challenges, and Direct Comparison with High-Sensitivity Flow Cytometry

The 2016 International Myeloma Working Group consensus recommendations emphasize high-sensitivity methods for minimal residual disease (MRD) detection, treatment response assessment, and prognostication. Next-generation sequencing (NGS) of IGH gene rearrangements is highly specific and sensitive, bu...

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Detalhes bibliográficos
Publicado no:J Mol Diagn
Main Authors: Ho, Caleb, Syed, Mustafa, Roshal, Mikhail, Petrova-Drus, Kseniya, Moung, Christine, Yao, Jinjuan, Quesada, Andres E., Benhamida, Jamal, Vanderbilt, Chad, Liu, Ying, Zhu, Menglei, Yu, Wayne, Maciag, Lidia, Wang, Meiyi, Ma, Yuanyuan, Gao, Qi, Rustad, Even H., Hultcrantz, Malin, Diamond, Benjamin T., Zheng-Lin, Binbin, Huang, Ying, Hutt, Kasey, Miller, Jeffrey E., Dogan, Ahmet, Nafa, Khedoudja, Landgren, Ola, Arcila, Maria E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2021
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7874334/
https://ncbi.nlm.nih.gov/pubmed/33217553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2020.10.015
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